STEM CELL THERAPY: TRANSFORMATIVE APPLICATIONS IN GYNECOLOGY AND REPRODUCTIVE MEDICINE

This paper explores the potential applications of stem cell therapies in gynaecology and reproductive medicine, particularly for treating reproductive disorders, preserving fertility in gonadotoxic treatments, and generating functional oocytes and embryos. The goal is to evaluate the impact of stem cell-based therapies on women's health and their transformative potential in addressing various gynaecological conditions. A comprehensive review of recent studies and clinical trials involving stem cell therapies, including mesenchymal stem cells (MSCs), induced pluripotent stem cells (iPSCs), and platelet-rich plasma (PRP) therapy, was conducted. The focus was on the use of these therapies for treating conditions such as premature ovarian insufficiency (POI), polycystic ovary syndrome (PCOS), Asherman’s syndrome, and fertility preservation in patients undergoing gonadotoxic treatments. Stem cell therapies have shown promise in regulating hormone balance, repairing damaged tissues, and improving fertility outcomes. MSCs and iPSCs have demonstrated potential in restoring ovarian function, generating viable gametes, and enhancing implantation success in IVF. Cryopreservation techniques remain a standard method for fertility preservation, while newer approaches like iPSC-derived oocytes offer personalised infertility treatments. However, challenges related to ethical, legal, and economic factors remain. Stem cell-based therapies promise to transform gynaecology and reproductive medicine. These therapies offer new hope for women facing infertility, endometrial damage, and reproductive health challenges. Continued research and innovation are needed to overcome existing limitations and integrate these therapies into clinical practice.